AS-1842856 | B3343

AS-1842856 | B3343

Description: AS-1842856 is a potent and selective Foxo1 (forkhead box class O transcription factor 1) inhibitor (IC50 values are 33 nM at Foxo1 and >1 μM at Foxo3a and Foxo4); decreases Foxo-mediated promoter activity by 70%, 20% and 3% at Foxo1, Foxo4 and Foxo3, respectively. Inhibition of FoxO1-mediated transactivation with AS-1842856 leads to a dose-dependent decrease in expression of glucose-6 phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK) mRNA and inhibits glucogenesis in rat hepatoma Fao cells and a murine model of type 2 diabetes mellitus (T2DM).

Alternate Name/Synonyms: 5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid AS1842856

Appearance: White solid

Formulation:

CAS Number: 836620-48-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₂FN₃O₃347.39

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~2 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Tag Line: A potent and selective Foxo1 inhibitor

MDL Number:

PubChem CID: 72193864

PubChem CID Link: https://pubchem.ncbi.nlm.nih.gov/compound/72193864

SMILES: CCN1C=C(C(C2=C(C(F)=C(C=C12)NC3CCCCC3)N)=O)C(O)=O

InChi: InChI=1S/C18H22FN3O3/c1-2-22-9-11(18(24)25)17(23)14-13(22)8-12(15(19)16(14)20)21-10-6-4-3-5-7-10/h8-10,21H,2-7,20H2,1H3,(H,24,25)

InChi Key: MOMCHYGXXYBDCD-UHFFFAOYSA-N

Category: Biochemica