ASB2 Antibody (N-term) [APR04199G]

ASB2 Antibody (N-term) [APR04199G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ASB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the N-terminal region of human ASB2.

Cellular Localisation: Cytoplasm, cytoskeleton, stress fiber

Molecular Weight: 70212

Clone: Polyclonal

Gene Name: ASB2

Gene ID: 51676

Function: Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:16325183, PubMed:15590664) . Mediates Notch- induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (PubMed:21119685) . Required during embryonic heart development for complete heart looping (By similarity) . Required for cardiomyocyte differentiation (PubMed:32179481) .

Summary: Tissue Location: [Isoform 1]: Expressed in muscle cells.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Ankyrin repeat and SOCS box protein 2, ASB-2, ASB2