ASMT polyclonal Antibody | BS6425

ASMT polyclonal Antibody | BS6425 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IF

Application Range: WB: 1:500~1:2000 IF: 1:50~1:100

Background: Serotonin, a monoamine neurotransmitter associated with neuronal modulation of emotions, is synthesized by serotonergic neurons of the central nervous system through metabolism of the essential amino acid L-tryptophan. In the pineal gland, serotonin can be transformed into the circadian regulatory hormone melatonin by ASMT (acetylserotonin O-methyltransferase) which catalyzes the final reaction in the synthesis pathway. ASMTL (N-acetylserotonin O-methyltransferase-like protein) is a 621 amino acid protein with a putative catalytic S-adenosyl-L-methionine domain that shares high genetic homology to ASMT. The ASMTL protein is encoded by a gene from the PAR1 region of the X and Y chromosomes, which is considered to be a fusion product of two evolutionarily disparate genes. ASMTL, with potential cytoplasmic localization, is abundant in pancreas, placenta, fibroblast, thymus, prostate, testis, ovary and colon. Low expression levels are found in spleen, small intestine and leukocytes.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ASMT polyclonal Antibody detects endogenous levels of ASMT protein.

Molecular Weight: ~ 38 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Acetylserotonin O-methyltransferase; Hydroxyindole O-methyltransferase; HIOMT; ASMT

Immunogen: Recombinant full length Human ASMT.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Regulation of Apoptosis,Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,Death Receptor Signaling,