ASN-002 (GUSACITINIB) | B3318

ASN-002 (Gusacitinib) is a potent dual inhibitor of SYK/JAK kinases. ASN-002 displays strong antitumor activity in both hematological and solid tumor xenograft models. ASN-002 strongly suppresses the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively.

ASN-002 (Gusacitinib) is a potent dual inhibitor of SYK/JAK kinases. ASN-002 displays strong antitumor activity in both hematological and solid tumor xenograft models. ASN-002 strongly suppresses the SYK and JAK family kinase signaling pathways as measured in pLAT and pSTAT assays, respectively.

B3318 | ASN-002 (GUSACITINIB) DataSheet

Alternate Name/Synonyms: ASN002 1-[5,6-Dihydro-4-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5-oxopyrimido[4,5-d]pyridazin-2-yl]-4-piperidineacetonitrile

Appearance: Crystalline solid

Formulation:

CAS Number: 1425381-60-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₈N₈O₂

Molecular Weight: 460.54

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: >50 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent dual inhibitor of SYK/JAK kinases

MDL Number:

PubChem CID: 71269142

SMILES: C1CN(CCC1CC#N)C2=NC3=C(C(=O)NN=C3)C(=N2)NC4=CC=C(C=C4)N5CCC(CC5)O

InChi: InChI=1S/C24H28N8O2/c25-10-5-16-6-11-32(12-7-16)24-28-20-15-26-30-23(34)21(20)22(29-24)27-17-1-3-18(4-2-17)31-13-8-19(33)9-14-31/h1-4,15-16,19,33H,5-9,11-14H2,(H,30,34)(H,27,28,29)

InChi Key: NLFLXLJXEIUQDL-UHFFFAOYSA-N