AT-101 | 2380

AT-101 is the R-(-) enantiomer of Gossypol that acts as an inhibitor of the antiapoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and an inducer of the pro-apoptotic proteins noxa and puma. It induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway.

AT-101 is the R-(-) enantiomer of Gossypol that acts as an inhibitor of the antiapoptotic Bcl proteins (Bcl-2, Bcl-XL, Bcl-W, and Mcl-1) and an inducer of the pro-apoptotic proteins noxa and puma.

2380 | AT-101 DataSheet

Alternate Name/Synonyms: (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dim­ethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8­,8'-dicarboxaldehyde; (R)-Gossypol

Appearance: Light brown solid

Formulation: N/A

CAS Number: 90141-22-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₀H₃₀O₈

Molecular Weight: 518.56

Cell-Permeable?: Yes

Purity: ≥98% by TLC

Solubilities: DMSO (~50 mg/ml) or EtOH (~50 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A Bcl-2 inhibitor and apoptosis inducer

MDL Number: N/A

PubChem CID: 227456

SMILES: OC1=C(O)C(C(C)C)=C(C=C(C)C(C2=C(O)C(C(C([H])=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)=C4O)C4=C1C([H])=O

InChi: InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3

InChi Key: QBKSWRVVCFFDOT-UHFFFAOYSA-N