AT-7519 hydrochloride | 2816

AT-7519 is a potent CDK inhibitor with potential antineoplastic activity. AT-7519 displays potent antiproliferative activity (40-940 nM) in a panel of human tumor cell lines, and the mechanism of action is shown to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT-7519 causes cell cycle arrest followed by apoptosis in human tumor cells and inhibits tumor growth in human tumor xenograft models.

AT-7519 is a potent CDK inhibitor with potential antineoplastic activity. AT-7519 displays potent antiproliferative activity (40-940 nM) in a panel of human tumor cell lines, and the mechanism of action is shown to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines

2816 | AT-7519 hydrochloride DataSheet

Alternate Name/Synonyms: N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 902135-91-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₈Cl₃N₅O₂

Molecular Weight: 418.71

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: A potent CDK inhibitor

MDL Number: N/A

PubChem CID: 25033099

SMILES: C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl

InChi: InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H

InChi Key: PAOFPNGYBWGKCO-UHFFFAOYSA-N