AT9283 | 2432

A pan-Aurora kinase inhibitor (IC₅₀ = 3 nM for both Aurora A and B). AT9283 also potently inhibits several kinases including the JAK2 and 3 (IC₅₀’s 1.2 and 1.1 nM, respectively), c-Abl(IC₅₀ = 110 nM) and Abl/T315I (IC₅₀ = 4 nM).

AT9283 is a pan-Aurora kinase inhibitor (IC₅₀ = 3 nM for both Aurora A and B). AT9283 also potently inhibits several kinases including the JAK2 and 3 (IC₅₀’s 1.2 and 1.1 nM, respectively), c-Abl(IC₅₀ = 110 nM) and Abl/T315I (IC₅₀ = 4 nM).

2432 | AT9283 DataSheet

Alternate Name/Synonyms: 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea

Appearance: Off-white solid

Formulation: N/A

CAS Number: 896466-04-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₂₃N₇O₂

Molecular Weight: 381.43

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>70 mg/ml) or EtOH (>25 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A multi-targeted c-Abl, JAK2, Aurora A and B inhibitor

MDL Number: N/A

PubChem CID: 11696609

SMILES: C1CC1NC(=O)NC2=CNNC2=C3N=C4C=CC(=CC4=N3)CN5CCOCC5

InChi: InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13,20,25H,2-3,5-8,11H2,(H2,21,24,27)/b18-17-

InChi Key: VRXXZJLHPWWXIX-ZCXUNETKSA-N