ATAD2 Antibody (N-term) [APR31065G]

ATAD2 Antibody (N-term) [APR31065G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ATAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the N-terminal region of human ATAD2.

Cellular Localisation: Nucleus.

Molecular Weight: 158554

Clone: Polyclonal

Gene Name: ATAD2

Gene ID: 29028

Function: May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

Summary: Tissue Location: Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: ATPase family AAA domain-containing protein 2, AAA nuclear coregulator cancer-associated protein, ANCCA, ATAD2