ATF1 Polyclonal Antibody | E-AB-70146

ATF1 Polyclonal Antibody | E-AB-70146 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Activating transcription factor 1, ATF 1, atf1, ATF1 EWS fusion gene, ATF1 FUS fusion gene, ATF1, cAMP dependent transcription factor 1, cAMP-dependent transcription factor ATF-1, Cyclic AMP dependent transcription factor ATF 1, Cyclic AMP dependent transcription factor ATF1, Cyclic AMP-dependent transcription factor ATF-1, EWS AFT1, FUS ATF 1, FUS/ATF 1, Protein TREB36, RNA binding protein activating transcription factor 1 fusion protein, TREB 36, TREB36, TREB36 protein

Application: WB

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

Concentration: 0.59 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ATF1

Buffer: PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

Purification Method: Affinity purification

Dilution: WB 1:500-1:1000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 29 kDa

Molecular Weight(Observed): 29 kDa