ATF6 monoclonal Antibody | MB9072

ATF6 monoclonal Antibody | MB9072 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human,Mouse,Rat

Application: WB IHC FC

Application Range: WB:1:500-1:1,000 IHC:1:50-1:100 FC：1:50-1:100

Background: Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3') . Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: ATF6 monoclonal Antibody detects endogenous levels of ATF6 protein.

Molecular Weight: 75 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: cAMP-dependent transcription factor ATF-6 alpha, ATF6-alpha, ATF6, Activating transcription factor 6 alpha, Activating transcription factor 6, ATF 6, ATF6 alpha, ATF6, ATF6-alpha, ATF6A, ATF6A, cAMP dependent transcription factor ATF 6 alpha, cAMP-dependent transcription factor ATF-6 alpha, Cyclic AMP dependent transcription factor ATF 6 alpha, DKFZp686P2194, ESTM49, FLJ21663, Processed cyclic AMP dependent transcription factor ATF 6 alpha, Processed cyclic AMP-dependent transcription factor ATF-6 alpha,

Immunogen: Recombinant protein within full length sequence of human ATF6.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProG purified.

Pathway: