ATG2A Antibody (Center) [APR31140G]

ATG2A Antibody (Center) [APR31140G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ATG2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 702-731 amino acids from the Central region of human ATG2A.

Cellular Localisation: Preautophagosomal structure membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96BY7}. Lipid droplet {ECO:0000250|UniProtKB:Q96BY7}. Endoplasmic reticulum membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:P53855}. Note=Localizes to endoplasmic reticulum-autophagosome contact sites.

Molecular Weight: 212860

Clone: Polyclonal

Gene Name: ATG2A {ECO:0000303|PubMed:21887408, ECO:0000312|HGNC:HGNC:29028}

Gene ID: 23130

Function: Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:31271352, PubMed:30952800) . Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:31271352, PubMed:30952800) . Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:31271352, PubMed:30952800) . Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P) -containing membranes (PubMed:31271352) . Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Autophagy-related protein 2 homolog A, ATG2A, KIAA0404