ATG2B polyclonal Antibody | AP0773

ATG2B polyclonal Antibody | AP0773 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB:1:500~1:1000 IHC:1:50~1:200

Background: Atg2B (ATG2 autophagy related 2 homolog B) is a 2,078 amino acid protein belonging to the ATG2 family. Encoded by a gene that maps to human chromosome 14q32.2, Atg2B is conserved in chimpanzee, canine, bovine, mouse, chicken, zebrafish, fruit fly, mosquito and Caenorhabditis elegans. 16 known human ATG genes exist, of which four (Atg2B, Atg5, Atg9B and Atg12) possess mononucleotide repeats with seven or more nucleotides. Atg2B frameshift mutations may contribute to development of cancer via disruption of autophagy. Atg2B associates with Atg2A, which is also linked to frameshift mutations associated with gastric and colorectal carcinomas with high microsatellite instability, indicating that these two related proteins functionally interact. WIPI-4, which is phylogenetically related to both Atg18p and Atg21p, associates with Atg2B and reciprocally binds Atg2A.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ATG2B polyclonal Antibody detects endogenous levels of ATG2B protein.

Molecular Weight: ~ 233 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Autophagy-related protein 2 homolog B; ATG2B; C14orf103

Immunogen: A synthetic peptide corresponding to residues in Human ATG2B.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A