ATM (I1987) polyclonal Antibody | BS5505

ATM (I1987) polyclonal Antibody | BS5505 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB IHC

Application Range: IHC: 1:50~1:200

Background: The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ATM (I1987) polyclonal Antibody detects endogenous levels of ATM protein.

Molecular Weight: ~ 350 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: A-T mutated; A-T mutated homolog; AT complementation group A; AT complementation group C; AT complementation group D; AT complementation group E; AT mutated; AT protein; AT1; AT1; ATA; Ataxia telangiectasia gene mutated in human beings; Ataxia telangiectasia mutated; Ataxia telangiectasia mutated gene; Ataxia telangiectasia mutated homolog (human) ; Ataxia telangiectasia mutated homolog; ATC; ATD; ATDC; ATE; ATM; ATM; DKFZp781A0353; Human phosphatidylinositol 3 kinase homolog; MGC74674; OTT

Immunogen: Synthetic peptide, corresponding to amino acids 1957-2006 of Human ATM.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phospholipase Signaling,Regulation of Microtubule Dynamics,G Protein-coupled Receptors Signaling to MAPK Erk,ErbB HER Signaling,