ATM Kinase Inhibitor, KU-55933 | 1685

A potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively).

KU-55933A is a potent, selective and ATP-competitive inhibitor of ATM Kinase (Ki = 2.2 nM; IC₅₀ = 13 nM). Inhibits DNA-PK, mTOR, PI 3-K, PI 4-K, and ATR at much higher concentrations (IC₅₀ = 2500, 9300, 16600, >100000 and >100000 nM, respectively).

1685 | ATM Kinase Inhibitor, KU-55933 DataSheet

Alternate Name/Synonyms: 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933

Appearance: White solid

Formulation: N/A

CAS Number: 587871-26-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₁₇NO₃S₂

Molecular Weight: 395.49

Cell-Permeable?: Yes

Purity: ≥97% by HPLC

Solubilities: DMSO (100 mM) and Ethanol (50 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An ATM kinase inhibitor

MDL Number: MFCD08276985

PubChem CID: 5278396

SMILES: C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

InChi: InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2

InChi Key: XRKYMMUGXMWDAO-UHFFFAOYSA-N