ATM Monoclonal Antibody | E-AB-22251

ATM Monoclonal Antibody | E-AB-22251 | Gentaur UK, US & Europe Distribution

Type: Monoclonal Antibody

Synonyms: A-T mutated, A-T mutated homolog, AT mutated, AT1, ATA, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog (human), Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM serine/threonine kinase, ATM, DKFZp781A0353, MGC74674, OTTHUMP00000232981, Serine protein kinase ATM, Serine-protein kinase ATM, Serine/threonine-protein kinase ATM, Tefu, TEL1, TEL1, telomere maintenance 1, homolog, TELO1, Telomere fusion protein

Application: IHC-p

Reactivity: Human, Mouse, Rat

Host: Mouse

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Protein of ATM of ATM

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Purification Method: Protein A purification

Dilution: IHC 1:100-200

Clone: Clone:1D1

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A