ATM (phospho S1981) polyclonal Antibody | BS94001

ATM (phospho S1981) polyclonal Antibody | BS94001 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Application: WB ICC/IF IHC IP

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:100

Background: Serine / threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thus acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST] -Q. Phosphorylates 'Ser-139' of histone variant H2AX / H2AFX at double strand breaks (DSBs), recover equilibrium DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain Allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, Soaccessability to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as A genre of activation of ABL1 and SAPK. May play a role in vesicle and / or protein transport. Could play A role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: ATM (phospho S1981) polyclonal Antibody detects endogenous levels of ATM protein only when phosphorylated at S1981.

Molecular Weight: 351 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: A-T mutated, A-T mutated, A-T mutated homolog, AT mutated, AT1, ATA, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog (human), Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM serine/threonine kinase, ATM, DKFZp781A0353, MGC74674, OTTHUMP00000232981, Serine protein kinase ATM, Serine-protein kinase ATM, Serine/threonine-protein kinase ATM, Tefu, TEL1, TEL1, telomere maintenance 1, homolog, TELO1, Telomere fusion protein Antibody,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser1981 of human ATM.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: ProA affinity purified

Pathway: