ATOH8 Antibody (N-term) [APR14094G]

ATOH8 Antibody (N-term) [APR14094G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This ATOH8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human ATOH8.

Cellular Localisation: Nucleus. Nucleus speckle. Cytoplasm {ECO:0000250|UniProtKB:Q99NA2}

Molecular Weight: 34644

Clone: Polyclonal

Gene Name: ATOH8 (HGNC:24126)

Gene ID: 84913

Function: Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (PubMed:24236640) . Regulates endothelial cell proliferation, migration and tube-like structures formation (PubMed:24463812) . Modulates endothelial cell differentiation through NOS3 (PubMed:24463812) . May be implicated in specification and differentiation of neuronal cell lineages in the brain (By similarity) . May participate in kidney development and may be involved in podocyte differentiation (By similarity) . During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (By similarity) . During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (By similarity) . Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (PubMed:24236640) . Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (By similarity) .

Summary: Tissue Location: Expressed in lung, liver, kidney, heart and pancreas. Expressed in endothel of umbilical vessels

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Protein atonal homolog 8, Class A basic helix-loop-helix protein 21, bHLHa21, Helix-loop-helix protein hATH-6, hATH6, ATOH8, ATH6, BHLHA21