Atorvastatin | 2278

A cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase (IC₅₀ = 154 nM) a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. In addition to inhibiting cholesterol synthesis, atorvastatin reduces the production of low-density lipoprotein (LDL).

Atorvastatin is a potent HMG-CoA reductase inhibitor

2278 | Atorvastatin DataSheet

Alternate Name/Synonyms: 2-​(4-​fluorophenyl)-​βR,​δR-​dihydroxy-​5-​(1-​methylethyl)-​3-​phenyl- ​4-​[(phenylamino)carbonyl]-​1H-​pyrrole-​1-​heptanoic acid

Appearance: White solid

Formulation: N/A

CAS Number: 134523-00-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₃₅FN₂O₅

Molecular Weight: 558.64

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (~15 mg/ml) or EtOH (~0.5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent HMG-CoA reductase inhibitor

MDL Number: MFCD00899261

PubChem CID: 60823

SMILES: CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4

InChi: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1

InChi Key: XUKUURHRXDUEBC-KAYWLYCHSA-N