ATP12A Antibody (Center) [APR15086G]

ATP12A Antibody (Center) [APR15086G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ATP12A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 833-859 amino acids from the Central region of human ATP12A.

Cellular Localisation: Apical cell membrane; Multi-pass membrane protein

Molecular Weight: 115511

Clone: Polyclonal

Gene Name: ATP12A {ECO:0000303|PubMed:29391451, ECO:0000312|HGNC:HGNC:13816}

Gene ID: 479

Function: The catalytic subunit of a H (+) /K (+) ATPase and/or Na (+) /K (+) ATPase pump which transports K (+) ions in exchange for Na (+) and/or H (+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K (+) ions into the cell while transporting Na (+) and/or H (+) ions to the extracellular compartment (PubMed:9774385, PubMed:7485470, PubMed:8853415, PubMed:11341842) . Involved in the maintenance of electrolyte homeostasis through K (+) ion absorption in kidney and colon (By similarity) . In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (PubMed:29391451) .

Summary: Tissue Location: Expressed in airway epithelial cells (at protein level) (PubMed:29391451) . Found in skin and kidney. Detected in prostate basal cells (at protein level) . Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: Potassium-transporting ATPase alpha chain 2, Non-gastric H (+) /K (+) ATPase subunit alpha, Proton pump, ATP12A, ATP1AL1