ATP2C1 Antibody (C-term) [APG02102G]

ATP2C1 Antibody (C-term) [APG02102G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ATP2C1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 882-909 amino acids from the C-terminal region of human ATP2C1.

Cellular Localisation: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi-pass membrane protein. Note=During neuron differentiation, shifts from juxtanuclear Golgi position to multiple Golgi structures distributed over the neural soma with a predominance in the apical dendritic trunk {ECO:0000250|UniProtKB:Q80XR2}

Molecular Weight: 100577

Clone: Polyclonal

Gene Name: ATP2C1 {ECO:0000303|PubMed:10615129, ECO:0000312|HGNC:HGNC:13211}

Gene ID: 27032

Function: ATP-driven pump that supplies the Golgi apparatus with Ca (2+) and Mn (2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway (PubMed:16192278, PubMed:30923126, PubMed:21187401, PubMed:12707275, PubMed:20439740) . Within a catalytic cycle, acquires Ca (2+) or Mn (2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state (PubMed:16192278, PubMed:16332677, PubMed:30923126) . Plays a primary role in the maintenance of Ca (2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology (PubMed:20439740, PubMed:14632183) . Responsible for loading the Golgi stores with Ca (2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity (PubMed:14632183, PubMed:10615129, PubMed:20439740) . Participates in Ca (2+) and Mn (2+) ions uptake into the Golgi store of hippocampal neurons and regulates protein trafficking required for neural polarity (By similarity) . May also play a role in the maintenance of Ca (2+) and Mn (2+) homeostasis and signaling in the cytosol while preventing cytotoxicity (PubMed:21187401) .

Summary: Tissue Location: Found in most tissues except colon, thymus, spleen and leukocytes (PubMed:15831496) . Expressed in keratinocytes (at protein level) (PubMed:15831496, PubMed:14632183)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Calcium-transporting ATPase type 2C member 1, ATPase 2C1, ATP-dependent Ca (2+) pump PMR1, ATP2C1, KIAA1347, PMR1L