ATP6V1B1 Antibody (C-term) [APG02141G]

ATP6V1B1 Antibody (C-term) [APG02141G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ATP6V1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 472-501 amino acids from the C-terminal region of human ATP6V1B1.

Cellular Localisation: Apical cell membrane. Basolateral cell membrane {ECO:0000250|UniProtKB:Q91YH6}

Molecular Weight: 56833

Clone: Polyclonal

Gene Name: ATP6V1B1

Gene ID: 525

Function: Non-catalytic subunit of the V1 complex of vacuolar (H+) - ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:16769747) . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091) . Essential for the proper assembly and activity of V- ATPase (PubMed:16769747) . In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification (PubMed:16769747) . Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity) .

Summary: Tissue Location: Kidney; localizes to early distal nephron, encompassing thick ascending limbs and distal convoluted tubules (at protein level) (PubMed:29993276, PubMed:16769747) . Expressed in the cochlea and endolymphatic sac (PubMed:9916796)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: V-type proton ATPase subunit B, kidney isoform, V-ATPase subunit B 1, Endomembrane proton pump 58 kDa subunit, Vacuolar proton pump subunit B 1, ATP6V1B1, ATP6B1, VATB, VPP3