ATP7A (H640) polyclonal Antibody | BS3695

ATP7A (H640) polyclonal Antibody | BS3695 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: ATP7A (also known as Copper-transporting ATPase 1) functions as a transmembrane copper-translocating P-type ATPase and plays a vital role in systemic copper absorption in the gut and copper reabsorption in the kidney. Polarized epithelial cells such as Madin-Darby canine kidney cells are a physiologically relevant model for systemic copper absorption and reabsorption in vivo. Although ATP7A is not detectable in most normal tissues, it is expressed in a considerable fraction of many common tumor types. Increased expression of ATP7A renders cells resistant to cisplatin and carboplatin. Mutations in the ATP7A gene result in Menkes disease, which is fatal in early childhood.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ATP7A (H640) polyclonal Antibody detects endogenous levels of ATP7A protein.

Molecular Weight: ~ 163 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Copper-transporting ATPase 1; Copper pump 1; Menkes disease-associated protein; ATP7A; MC1; MNK

Immunogen: Synthetic peptide, corresponding to amino acids 620-670 of Human ATP7A.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: