ATXN1 Antibody (S776) [APG03177G]

ATXN1 Antibody (S776) [APG03177G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 amino acids from human ATXN1.

Cellular Localisation: Cytoplasm. Nucleus Note=Colocalizes with USP7 in the nucleus

Molecular Weight: 86923

Clone: Polyclonal

Gene Name: ATXN1

Gene ID: 6310

Function: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression. Binds RNA in vitro. May be involved in RNA metabolism (PubMed:21475249) . In concert with CIC and ATXN1L, involved in brain development (By similarity) .

Summary: Tissue Location: Widely expressed throughout the body.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IF, WB

Dilution: WB--1:2000

Synonyms: Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1