ATXN3 Polyclonal Antibody | E-AB-40246

ATXN3 Polyclonal Antibody | E-AB-40246 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: AT3, Ataxin 3, ataxin 3 variant h, ataxin 3 variant m, ataxin 3 variant ref, Ataxin-3, ATX3, EC 3.4.22, JOS, Machado Joseph disease, MJD, Olivopontocerebellar ataxia 3, OTTHUMP00000221583, Rsca3, Spinocerebellar ataxia type 3 protein

Application: WB, IHC

Reactivity: Human

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Background: Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Concentration: 2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant Human Ataxin-3 protien

Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 41 kDa

Molecular Weight(Observed): 41 kDa, 22 kDa