Aurora-A Antibody (Aurka)| F44002-0.08ML

Aurora-A Antibody (Aurka)| F44002-0.08ML | Gentaur UK, US & Europe Distribution

Background: Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Mouse

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the Aurka antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This Aurka antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 93-120 from the mouse protein was used as the immunogen for this Aurka antibody.

Storage: Aliquot the Aurka antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A