AV-412 tosylate | B2052

AV-412 is a dual EGFR/ErbB2 kinase inhibitor with IC₅₀ values of 43 nM and 282 nM, respectively. Displays anticancer activity.

AV-412 is a dual EGFR/ErbB2 kinase inhibitor with IC₅₀ values of 43 nM and 282 nM, respectively. Displays anticancer activity.

B2052 | AV-412 tosylate DataSheet

Alternate Name/Synonyms: N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide bis(4-methylbenzenesulfonate); MP-412; MP412

Appearance: White solid

Formulation: N/A

CAS Number: 451493-31-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₁H₄₄ClFN₆O₇S₂

Molecular Weight: 850.24

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A dual EGFR/ErbB2 kinase inhibitor

MDL Number: N/A

PubChem CID: 11700696

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC=C(C=C1)S(=O)(=O)O.CC(C)(C#CC1=CC2=C(C=C1NC(=O)C=C)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)N4CCN(CC4)C

InChi: InChI=1S/C27H28ClFN6O.2C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;2*1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2*2-5H,1H3,(H,8,9,10)

InChi Key: GTWJVFFZCKODEV-UHFFFAOYSA-N