Avasimibe | 9506

Avasimibe is an orally bioavailable inhibitor of the acyl coenzyme A: cholesterol acyltransferase (ACAT) (IC₅₀ = 60 nM). Avasimibe also inhibits major drug metabolizing enzymes such as CYP2C9 (IC₅₀ = 2.9 µM ), CYP1A2 (IC₅₀ = 13.9 µM), and CYP2C19 (IC₅₀ = 26.5 µM).

Avasimibe is an orally bioavailable inhibitor of the acyl coenzyme A: cholesterol acyltransferase (ACAT) (IC₅₀ = 60 nM).

9506 | Avasimibe DataSheet

Alternate Name/Synonyms: [2,6-di(propan-2-yl)phenyl] N-[2-[2,4,6-tri(propan-2-yl)phenyl]acetyl]sulfamate; CI-1011; PD 148515

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 166518-60-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₄₃NO₄S

Molecular Weight: 501.72

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor

MDL Number: MFCD00934956

PubChem CID: 166558

SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)OS(=O)(=O)NC(=O)CC2=C(C=C(C=C2C(C)C)C(C)C)C(C)C

InChi: InChI=1S/C29H43NO4S/c1-17(2)22-14-25(20(7)8)27(26(15-22)21(9)10)16-28(31)30-35(32,33)34-29-23(18(3)4)12-11-13-24(29)19(5)6/h11-15,17-21H,16H2,1-10H3,(H,30,31)

InChi Key: PTQXTEKSNBVPQJ-UHFFFAOYSA-N