Axin2 polyclonal Antibody | BS90114

Axin2 polyclonal Antibody | BS90114 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC

Application Range: WB:1:500-1:2,000 ICC:1:50-1:200 IHC:1:10-1:50

Background: b-catenin is a component of both the cadherin cell adhesion system and the Wnt signaling pathway. Wnt signaling increases the amount of b-catenin, by preventing its ubiquitination and degradation, allowing its direct interaction with transcription factors of the lymphoid enhancer factor-T cell factor family and modulation of gene expression. Axin is involved in the degradation of b-catenin by acting as a scaffold to form a complex between b-catenin, adenomatous polyposis coli (APC) and GSK-3b. APC, which is phosphorylated by GSK-3b, induces degradation of b-catenin, thus inhibiting Wnt signal transduction. Conductin is 45% identical to axin and appears to play a similar role to axin in the Wnt signaling pathway.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Axin2 polyclonal Antibody detects endogenous levels of Axin2 protein.

Molecular Weight: 94 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Axil, AXIN2, Axil, Axin like protein, Axin-2, Axin-like protein, Axin2, AXIN2, Axis inhibition protein 2, Conductin, DKFZp781B0869, MGC10366, MGC126582,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: