AZ-191 | B3288

AZ-191 is a potent and selective DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) inhibitor (IC50 = 17 nM). AZ-191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B is amplified in certain cancers and may be an oncogene.

AZ-191 is a potent and selective DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) inhibitor (IC50 = 17 nM). AZ-191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B is amplified in certain cancers and may be an oncogene.

B3288 | AZ-191 DataSheet

Alternate Name/Synonyms: N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine AZ191

Appearance: Off-white solid

Formulation:

CAS Number: 1594092-37-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₇N₇O

Molecular Weight: 429.52

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >35 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent and selective DYRK1B inhibitor

MDL Number:

PubChem CID: 72716071

SMILES: CN2C=C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)C1=CC=NC=C12

InChi: InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)

InChi Key: ZYVXTMKTGDARKR-UHFFFAOYSA-N