AZ-304 | B2571

AZ-304 is a potent, ATP-competitive dual BRAF kinase inhibitor that inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC₅₀s of 79 nM, 38 nM and 68 nM, respectively. In addition, AZ-304 exhibits significant effect on other kinases such as p38 (IC₅₀, 6 nM), CSF1R (IC₅₀, 35 nM). AZ-304 exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status.

AZ-304 is a potent, ATP-competitive dual BRAF kinase inhibitor that inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC₅₀s of 79 nM, 38 nM and 68 nM, respectively. In addition, AZ-304 exhibits significant effect on other kinases such as p38 (IC₅₀, 6 nM), CSF1R (IC₅₀, 35 nM). AZ-304 exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status.

B2571 | AZ-304 DataSheet

Alternate Name/Synonyms: 3-(2-cyanopropan-2-yl)-N-(3-((7-methoxyquinazolin-4-yl)amino)-4-methylphenyl)benzamide, AZ304, AZ 304

Appearance: Crystalline solid

Formulation:

CAS Number: 942507-42-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₂₅N₅O₂

Molecular Weight: 451.53

Cell-Permeable?: True

Purity: ≥98%

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent dual BRAF inhibitor

MDL Number:

PubChem CID: 16202218

SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=NC=NC4=C3C=CC(=C4)OC

InChi: InChI=1S/C27H25N5O2/c1-17-8-9-20(31-26(33)18-6-5-7-19(12-18)27(2,3)15-28)13-23(17)32-25-22-11-10-21(34-4)14-24(22)29-16-30-25/h5-14,16H,1-4H3,(H,31,33)(H,29,30,32)

InChi Key: NGWQZRWVYYFTHC-UHFFFAOYSA-N