AZ-505 ditrifluoroacetate | B1883

AZ-505 is a potent and highly selective inhibitor of SMYD2 (IC₅₀ = 0.12 μM) with potential anticancer activity. Displays >600-fold selectivity over other histone methyltransferases, such as SMYD3 (IC₅₀>83.3 μM), DOT1L (IC₅₀>83.3 μM) and EZH2 (IC₅₀>83.3 μM).

AZ-505 is a potent and highly selective inhibitor of SMYD2 (IC₅₀ = 0.12 μM) with potential anticancer activity. Displays >600-fold selectivity over other histone methyltransferases, such as SMYD3 (IC₅₀>83.3 μM), DOT1L (IC₅₀>83.3 μM) and EZH2 (IC₅₀>83.3 μM).

B1883 | AZ-505 ditrifluoroacetate DataSheet

Alternate Name/Synonyms: N-cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-[2-(5-hydroxy-3-oxo-4H-1,4-benzoxazin-8-yl)ethylamino]ethyl]propenamide bis(2,2,2-trifluoroacetate)

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1035227-44-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₃H₄₀Cl₂F₆N₄O₈

Molecular Weight: 805.59

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent and highly selective inhibitor of SMYD2

MDL Number: N/A

PubChem CID: 78357790

SMILES: C1CCC(CC1)N(CCNCCC2=C3C(=C(C=C2)O)NC(=O)CO3)C(=O)CCNCCC4=CC(=C(C=C4)Cl)Cl.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

InChi: InChI=1S/C29H38Cl2N4O4.2C2HF3O2/c30-23-8-6-20(18-24(23)31)10-13-32-15-12-27(38)35(22-4-2-1-3-5-22)17-16-33-14-11-21-7-9-25(36)28-29(21)39-19-26(37)34-28;2*3-2(4,5)1(6)7/h6-9,18,22,32-33,36H,1-5,10-17,19H2,(H,34,37);2*(H,6,7)

InChi Key: LTZSXVZCRINTGV-UHFFFAOYSA-N