AZ-6102 | B1200

AZ-6102 is a potent TNKS1/2 inhibitor (Tankyrase) that displays >100-fold selectivity against other poly (ADP-ribose) polymerase (PARP) family enzymes and inhibits Wnt pathway with IC₅₀ value of 5 nM in DLD-1 cells. Inhibition of the PARP catalytic domain of the tankyrases is known to inhibit the Wnt pathway via increased stabilization of Axin. Wnt pathway plays important role in cancer, tissue homeostasis; germline mutations of various Wnt pathway components as Axin can lead to oncogenesis.

AZ-6102 is a potent TNKS1/2 inhibitor (Tankyrase) that displays >100-fold selectivity against other poly (ADP-ribose) polymerase (PARP) family enzymes and inhibits Wnt pathway with IC₅₀ value of 5 nM in DLD-1 cells. Inhibition of the PARP catalytic domain of the tankyrases is known to inhibit the Wnt pathway via increased stabilization of Axin. Wnt pathway plays important role in cancer, tissue homeostasis; germline mutations of various Wnt pathway components as Axin can lead to oncogenesis.

B1200 | AZ-6102 DataSheet

Alternate Name/Synonyms: 2-(4-(6-((3R,5S)-3,5-dimethylpiperazin-1-yl)-4-methylpyridin-3-yl)phenyl)-7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Appearance: Off white solid

Formulation: N/A

CAS Number: 1645286-75-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₈N₆O

Molecular Weight: 428.54

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO(>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent TNKS1/2 inhibitor (Tankyrase) having greater selectivity against PARP family enzymes and inhibits Wnt pathway

MDL Number: N/A

PubChem CID: 91663328

SMILES: CC1CN(CC(N1)C)C2=NC=C(C(=C2)C)C3=CC=C(C=C3)C4=NC(=O)C5=C(N4)N(C=C5)C

InChi: InChI=1S/C25H28N6O/c1-15-11-22(31-13-16(2)27-17(3)14-31)26-12-21(15)18-5-7-19(8-6-18)23-28-24-20(25(32)29-23)9-10-30(24)4/h5-12,16-17,27H,13-14H2,1-4H3,(H,28,29,32)/t16-,17+

InChi Key: WCPTUQOMNJBIET-CALCHBBNSA-N