AZ-960 | B2065

AZ-960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM. AZ-960 induces growth arrest and apoptosis of human T-cell lymphotropic virus type 1, HTLV-1-infected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of Jak2 and Bcl-2 family proteins including Bcl-2 and Mcl-1.

AZ-960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM. AZ-960 induces growth arrest and apoptosis of human T-cell lymphotropic virus type 1, HTLV-1-infected T cells (MT-1 and MT-2) in parallel with downregulation of the phosphorylated forms of Jak2 and Bcl-2 family proteins including Bcl-2 and Mcl-1.

B2065 | AZ-960 DataSheet

Alternate Name/Synonyms: (S)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 905586-69-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₆F₂N₆

Molecular Weight: 354.36

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and specific JAK2 kinase inhibitor

MDL Number: N/A

PubChem CID: 25099184

SMILES: CC1=CC(=NN1)NC2=C(C=C(C(=N2)NC(C)C3=CC=C(C=C3)F)C#N)F

InChi: InChI=1S/C18H16F2N6/c1-10-7-16(26-25-10)23-18-15(20)8-13(9-21)17(24-18)22-11(2)12-3-5-14(19)6-4-12/h3-8,11H,1-2H3,(H3,22,23,24,25,26)/t11-/m0/s1

InChi Key: SUNXHXDJOIXABJ-NSHDSACASA-N