Azamulin | 2915

Azamulin is a derivative of the antibiotic pleuromutilin. It is a highly selective inhibitor of the CYP3A family (IC50 = 0.03-0.24 μM as reported in Stresser et al., DMD, January 2004 vol. 32 no. 1 p105-112). Azamulin is a 15 and 13 fold more potent inhibitor of CYP3A4 compared to CYP3A5 or CYP3A7 respectively making it very useful for CYP3A4 activity assays and can be used as a benchmark in CYP3A4 inhibitor screening assays. It is at least 100 fold selective over other CYP isoforms (except CYP2J2 ~ 50-fold).

Azamulin is an azole derivative of the antibiotic pleuromutilin. It is a highly selective and potent inhibitor of the Cytochrome P450 3A family, specifically CYP3A4.

2915 | Azamulin DataSheet

Alternate Name/Synonyms: (5-Amino-1H-1,2,4-triazol-3-yl)thio]acetic acid (3aS,4R,5S,6R,8R,9R,9aR,10R)-6-ethyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester,14-O-(5-(2-Amino1,3,4-triazolyl)thioacetyl)dihydromutilin, Antibiotic TDM 85-530

Appearance: White to beige powder

Formulation: N/A

CAS Number: 76530-44-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₃₈N₄O₄S

Molecular Weight: 478.65

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~10 mg/ml), Acetonitrile (~4.8 mg/ml)

Handling: Protect from air, light and moisture

Country of Origin: USA

Tag Line: A potent and specific inhibitor of CYP3A4

MDL Number: MFCD00865055

PubChem CID: 3086060

SMILES: CCC1(CC(C2(C(CCC3(C2C(=O)CC3)C(C1O)C)C)C)OC(=O)CSC4=NNC(=N4)N)C

InChi: InChI=1S/C24H38N4O4S/c1-6-22(4)11-16(32-17(30)12-33-21-26-20(25)27-28-21)23(5)13(2)7-9-24(14(3)19(22)31)10-8-15(29)18(23)24/h13-14,16,18-19,31H,6-12H2,1-5H3,(H3,25,26,27,28)/t13?,14-,16+,18-,19-,22+,23-,24-/m0/s1

InChi Key: FMHQJXGMLMSMLC-GUNZQCIYSA-N