AZD-0156 | B1305

AZD-0156 is an orally bioavailable Ataxia Telangiectasia Mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD-0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling.

AZD-0156 is an orally bioavailable Ataxia Telangiectasia Mutated (ATM) kinase inhibitor, with potential chemo-/radio-sensitizing and antineoplastic activities. AZD-0156 targets and binds to ATM, thereby inhibiting the kinase activity of ATM and ATM-mediated signaling.

B1305 | AZD-0156 DataSheet

Alternate Name/Synonyms: 8-[6-[3-(dimethylamino)propoxy]-3-pyridyl]-3-methyl-1-tetrahydropyran-4-yl-imidazo[4,5-c]quinolin-2-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1821428-35-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₃₁N₅O₃

Molecular Weight: 461.57

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent Ataxia Telangiectasia Mutated (ATM) kinase inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(N1C2CCOCC2)N(C)C3=C1C4=CC(C5=CC=C(OCCCN(C)C)N=C5)=CC=C4N=C3

InChi: InChI=1S/C26H31N5O3/c1-29(2)11-4-12-34-24-8-6-19(16-28-24)18-5-7-22-21(15-18)25-23(17-27-22)30(3)26(32)31(25)20-9-13-33-14-10-20/h5-8,15-17,20H,4,9-14H2,1-3H3

InChi Key: AOTRIQLYUAFVSC-UHFFFAOYSA-N