AZD-1981 | 9611

AZD-1981 is a potent and selective antagonist of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2) with an IC₅₀ value of 4 nM; blocks functional responses in eosinophils, Th2 cells and basophils. It exhibits similar potency irrespective of the cell type, DP2 agonist or species used.

AZD-1981 is a potent and selective antagonist of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2) with an IC₅₀ value of 4 nM; blocks functional responses in eosinophils, Th2 cells and basophils. It exhibits similar potency irrespective of the cell type, DP2 agonist or species used.

9611 | AZD-1981 DataSheet

Alternate Name/Synonyms: 2-(4-acetamido-3-((4-chlorophenyl)thio)-2-methyl-1H-indol-1-yl)acetic acid

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 802904-66-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₇ClN₂O₃S

Molecular Weight: 388.87

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective antagonist of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2)

MDL Number: N/A

PubChem CID: 11292191

SMILES: CC1=C(C2=C(N1CC(=O)O)C=CC=C2NC(=O)C)SC3=CC=C(C=C3)Cl

InChi: InChI=1S/C19H17ClN2O3S/c1-11-19(26-14-8-6-13(20)7-9-14)18-15(21-12(2)23)4-3-5-16(18)22(11)10-17(24)25/h3-9H,10H2,1-2H3,(H,21,23)(H,24,25)

InChi Key: JWYIGNODXSRKGP-UHFFFAOYSA-N