AZD-4573 | B3319

AZD-4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM). It displays rapid induction of apoptosis and subsequent cell death broadly across hematologic cancer models in vitro, and MCL-1 depletion in a dose- and time-dependent manner.

AZD-4573 is a potent and highly selective CDK9 inhibitor (IC50 of <4 nM). It displays rapid induction of apoptosis and subsequent cell death broadly across hematologic cancer models in vitro, and MCL-1 depletion in a dose- and time-dependent manner.

B3319 | AZD-4573 DataSheet

Alternate Name/Synonyms: AZD4573 Cyclohexanecarboxami​de, 3-​(acetylamino)​-​N-​[5-​chloro-​4-​(5,​6-​dihydro-​5,​5-​dimethyl-​4H-​pyrrolo[1,​2-​b]​pyrazol-​3-​yl)​-​2-​pyridinyl]​-​, (1S,​3R)​-

Appearance: Crystalline solid

Formulation:

CAS Number: 2057509-72-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₈ClN₅O₂

Molecular Weight: 429.94

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >40 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent CDK9 inhibitor

MDL Number:

PubChem CID: 124155204

SMILES: CC(=O)NC1CCCC(C1)C(=O)NC2=NC=C(C(=C2)C3=C4CC(CN4N=C3)(C)C)Cl

InChi: InChI=1S/C22H28ClN5O2/c1-13(29)26-15-6-4-5-14(7-15)21(30)27-20-8-16(18(23)11-24-20)17-10-25-28-12-22(2,3)9-19(17)28/h8,10-11,14-15H,4-7,9,12H2,1-3H3,(H,26,29)(H,24,27,30)/t14-,15+/m0/s1

InChi Key: AVIWDYSJSPOOAR-LSDHHAIUSA-N