AZD-5582 | B2362

AZD-5582 is a potent IAP inhibitor that binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC₅₀ values of 15, 21, and 15 NM, respectively).

AZD-5582 is a potent IAP inhibitor that binds potently to the BIR3 domains of cIAP1, cIAP2, and XIAP (IC₅₀ values of 15, 21, and 15 NM, respectively).

B2362 | AZD-5582 DataSheet

Alternate Name/Synonyms: (S,S,2S,2′S)-N,N′-((1S,1′S,2R,2′R)-2,2′-(Hexa-2,4-diyne-1,6-diylbis(oxy))bis(2,3-dihydro-1H-indene-2,1-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-pyrrolidine-2-carboxamide,AZD5582

Appearance: Crystalline solid

Formulation:

CAS Number: 1258392-53-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₅₈H₇₈N₈O₈

Molecular Weight: 1015.29

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~10 mg/ml (DMSO) in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent IAP inhibitor

MDL Number:

PubChem CID: 9847690

SMILES: CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3C(CC4=CC=CC=C34)OCC#CC#CCOC5CC6=CC=CC=C6C5NC(=O)C7CCCN7C(=O)C(C8CCCCC8)NC(=O)C(C)NC)NC

InChi: InChI=1S/C58H78N8O8/c1-37(59-3)53(67)61-49(39-21-9-7-10-22-39)57(71)65-31-19-29-45(65)55(69)63-51-43-27-15-13-25-41(43)35-47(51)73-33-17-5-6-18-34-74-48-36-42-26-14-16-28-44(42)52(48)64-56(70)46-30-20-32-66(46)58(72)50(40-23-11-8-12-24-40)62-54(68)38(2)60-4/h13-16,25-28,37-40,45-52,59-60H,7-12,19-24,29-36H2,1-4H3,(H,61,67)(H,62,68)(H,63,69)(H,64,70)/t37-,38-,45-,46-,47+,48+,49-,50-,51-,52-/m0/s1

InChi Key: WLMCRYCCYXHPQF-ZVMUOSSASA-N