AZD-8186 | B1027

AZD-8186 is a potent and selective PI3Kβ/δ inhibitor. Displays potential to reduce growth of tumors dependent on dysregulated PTEN for growth.

AZD-8186 is a potent and selective PI3Kβ/δ inhibitor. Displays potential to reduce growth of tumors dependent on dysregulated PTEN for growth.

B1027 | AZD-8186 DataSheet

Alternate Name/Synonyms: (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1627494-13-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₅F₂N₃O₄

Molecular Weight: 457.47

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective PI3Kβ/δ inhibitor

MDL Number: N/A

PubChem CID: 52913813

SMILES: CC(C1=C2C(=CC(=C1)C(=O)N(C)C)C(=O)C=C(O2)N3CCOCC3)NC4=CC(=CC(=C4)F)F

InChi: InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

InChi Key: LMJFJIDLEAWOQJ-CQSZACIVSA-N