Description
AZD-8931 is a potent, ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3 (the IC₅₀ values are 4 nM, 3 nM and 4 nM, respectively).
AZD-8931 is a potent, ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3 (the IC₅₀ values are 4 nM, 3 nM and 4 nM, respectively).
Alternate Name/Synonyms: 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy]quinazoline; Sapitinib; Momelotinib.
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 848942-61-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₅ClFN₅O₃
Molecular Weight: 473.93
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>10 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent, ATP competitive and reversible inhibitor of EGFR (ErbB-1), Neu (ErbB-2) and ErbB-3
MDL Number: N/A
PubChem CID: 11488320
SMILES: CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC
InChi: InChI=1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2H3,(H,26,31)(H,27,28,29)
InChi Key: DFJSJLGUIXFDJP-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |
