AZD-9291 | 2674

AZD-9291 is a potent, third generation, mutant-selective EGFR tyrosine kinase inhibitor. It is effective against both EGFR-TKI sensitizing and resistance T790M mutations. Displays anticancer properties.

AZD-9291 is a potent, third generation, mutant-selective EGFR tyrosine kinase inhibitor. It is effective against both EGFR-TKI sensitizing and resistance T790M mutations. Displays anticancer properties.

2674 | AZD-9291 DataSheet

Alternate Name/Synonyms: N-​[2-​[[2-​(Dimethylamino)​ethyl]​methylamino]​-​4-​methoxy-​5-​[[4-​(1-​methyl-​1H-​indol-​3-​yl)​-​2-​pyrimidinyl]​amino]​phenyl]​- 2-​propenamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1421373-65-0

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₃N₇O₂

Molecular Weight: 499.61

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A mutant-selective EGFR tyrosine kinase inhibitor

MDL Number: N/A

PubChem CID: 71496458

SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

InChi: InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)

InChi Key: DUYJMQONPNNFPI-UHFFFAOYSA-N