AZD8835 | B1661

AZD8835 is a potent and selective inhibitor of PI3Kδ and PI3Kα with IC50 of 5.7 nM and 6.2 nM, with selectivity against PI3Kβ (IC50 431 nM) and PI3Kγ (IC50 90 nM).

AZD8835 is a potent and selective inhibitor of PI3Kδ and PI3Kα with IC50 of 5.7 nM and 6.2 nM, with selectivity against PI3Kβ (IC50 431 nM) and PI3Kγ (IC50 90 nM).

B1661 | AZD8835 DataSheet

Alternate Name/Synonyms: AZD8835; AZD 8835; AZD-8835; 1-(4-(5-(5-amino-6-(5-(tert-butyl)-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1H-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one

Appearance: Solid

Formulation: N/A

CAS Number: 1620576-64-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₃₁N₉O₃

Molecular Weight: 469.55

Cell-Permeable?: Yes

Purity: >98%

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A dual PI3Kα and PI3Kδ inhibitor

MDL Number: N/A

PubChem CID: 76685059

SMILES: CCN1C(=NC(=N1)C2CCN(CC2)C(=O)CCO)C3=CN=C(C(=N3)C4=NN=C(O4)C(C)(C)C)N

InChi: InChI=1S/C22H31N9O3/c1-5-31-19(26-18(29-31)13-6-9-30(10-7-13)15(33)8-11-32)14-12-24-17(23)16(25-14)20-27-28-21(34-20)22(2,3)4/h12-13,32H,5-11H2,1-4H3,(H2,23,24)

InChi Key: ZGRDYKFVDCFJCZ-UHFFFAOYSA-N