B-Raf Inhibitor 1 | 2599

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC₅₀s of 0.31 µM and 2 nM for A375 proliferation and A375 p-ERK respectively.

B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC₅₀s of 0.31 µM and 2 nM for A375 proliferation and A375 p-ERK respectively.

2599 | B-Raf Inhibitor 1 DataSheet

Alternate Name/Synonyms: N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]- 1,5-Isoquinolinediamine

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1093100-40-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₆H₁₉ClN₈

Molecular Weight: 478.94

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: Apotent and selective B-Raf inhibitor

MDL Number: N/A

PubChem CID: 44223999

SMILES: CC1=C(C2=C(C=C1)C(=NC=C2)NC3=CC=C(C=C3)Cl)NC4=C(C=CC=N4)C5=C6C(=NC=N5)N=CN6

InChi: InChI=1S/C26H19ClN8/c1-15-4-9-19-18(10-12-29-24(19)34-17-7-5-16(27)6-8-17)21(15)35-25-20(3-2-11-28-25)22-23-26(32-13-30-22)33-14-31-23/h2-14H,1H3,(H,28,35)(H,29,34)(H,30,31,32,33)

InChi Key: KKVYYGGCHJGEFJ-UHFFFAOYSA-N