Bacterial/Permeability-Increasing Protein, Human Neutrophil (BPI, CAP57) | 7288

Bactericidal/permeability increasing protein (BPI) is a 456 residue protein which is part of the innate immune system. BPI was initially identified in neutrophils, but is found in other tissues including the epithelial lining of mucus membranes. It is an endogenous antibiotic protein with potent killing activity against Gram-negative bacteria. It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the immune system; however BPI at certain concentrations can prevent this activation. Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.

7288 | Bacterial/Permeability-Increasing Protein Human Neutrophil BPI CAP57 DataSheet

Biomolecule/Target: BPI

Synonyms: BPI, CAP57

Alternates names: Small inducible cytokine A20 precursor, CCL20, Macrophage inflammatory protein 3 , MIP-3-, Liver and activation- regulated chemokine, CC chemokine LARC, chemokine exodus-1, CKb4, LARC, ST38, MIP3A, MIP-3a, SCYA20.

Taglines: An endogenous antibiotic protein with potent killing activity against Gram-negative bacteria

NCBI Gene ID #: 6364

NCBI Gene Symbol: CCL20

Gene Source: Human

Accession #: P78556

Recombinant: No

Source: Human Neutrophil

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: Determined by its ability to chemoattract human T cells using a concentration range of 7-70 ng/ml.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 8.0 kDa

Concentration: N/A

Appearance: Frozen

Physical form description: Frozen in 80 mM Citrate Phosphate, pH 5.6, 0.75 M NaCl.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A