Bafilomycin A1 | 1829

A highly potent and selective inhibitor of vacuolar H+-ATPases (V-ATPases) in vitro. It is effective in nanomolar concentrations in animal cells, plant cells and microorganisms; also selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca2+-ATPases, Na+/K+-ATPases and plasma membrane H+-ATPases. Also prevents autophagy at a late stage by inhibiting fusion between autophagosomes and lysosomes.

Bafilomycin A1 is a highly potent and selective inhibitor of vacuolar H⁺-ATPases (V-ATPases) in vitro. It is effective in nanomolar concentrations in animal cells, plant cells and microorganisms; also selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca²⁺-ATPases, Na⁺/K⁺-ATPases and plasma membrane H⁺-ATPases.

1829 | Bafilomycin A1 DataSheet

Alternate Name/Synonyms:

Appearance: Colorless film

Formulation: N/A

CAS Number: 88899-55-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₅H₅₈O₉

Molecular Weight: 622.84

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An inhibitor of vacuolar H⁺-ATPases (V-ATPases)

MDL Number: MFCD06795130

PubChem CID: 53321987

SMILES: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C

InChi: InChI=1S/C35H58O9/c1-19(2)32-24(7)27(36)18-35(40,44-32)26(9)31(38)25(8)33-28(41-10)14-12-13-20(3)15-22(5)30(37)23(6)16-21(4)17-29(42-11)34(39)43-33/h12-14,16-17,19,22-28,30-33,36-38,40H,15,18H2,1-11H3/b14-12-,20-13+,21-16+,29-17-/t22-,23+,24-,25-,26-,27+,28-,30-,31+,32+,33?,35+/m0/s1

InChi Key: XDHNQDDQEHDUTM-MKFMMVOISA-N