BAG5 polyclonal Antibody | BS61560

BAG5 polyclonal Antibody | BS61560 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Bag-5 (Bcl-2-associated athanogene 5),also known as Bag family molecular chaperone regulator 5,is a member of the Bag family of proteins and contains four Bag domains.Via their Bag domain, Bag proteins bind with high affinity to the HSC 70/HSP 70 ATPase domain, regulating chaperone activity and apoptosis.Bag-5 is a component of the HSP 70/Parkin complex and acts to inhibit Parkin E3 ubiquitin ligase activity and HSP 70 chaperone activity. In this complex, Bag-5 directly interacts with the ATPase domain of HSP 70 and the N-terminal linker region of Parkin. Bag-5 expression is induced upon dopaminergic neuron injury and functions to sensitize the neurons to injuryinduced cell death. In addition, Bag-5 may be a useful target in therapies for neurodegenerative diseases such as Parkinson’s disease which is caused by a mutation in the gene encoding Parkin.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BAG5 polyclonal Antibody detects endogenous levels of BAG5 protein.

Molecular Weight: ~ 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: BAG family molecular chaperone regulator 5; BAG-5; Bcl-2-associated athanogene 5

Immunogen: Synthetic peptide, corresponding to amino acids 11-55 of Human BAG5

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)

Pathway: