BAI3 polyclonal Antibody | BS60780

BAI3 polyclonal Antibody | BS60780 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Brain-specific angiogenesis inhibitors, including BAI-1, BAI-2, and BAI-3, are integral membrane proteins belonging to the G-protein coupled receptor 2 family. In addition to inhibiting angiogenesis in the brain, BAI proteins are also expressed in the heart, thymus, skeletal muscle, and a variety of cell lines. BAI-3 is predominantly expressed in brain. Reduced expression may be observed in some glioblastoma cell lines suggesting that BAI-3 may function in the suppression of glioblastoma. Localization of BAI-3 in most neurons of the cerebral cortex is analogous with BAI-1 and BAI-2 expression in the adult brain, but varies in the developing brain. The activity of brain-specific angiogenesis inhibitor proteins has been inversely correlated with vascularization in some cancer tissues. BAI-3 activity may be significant in the early phases of ishemia-induced brain angiogenesis and in brain tumor progression. A better understanding of the anti-angiogenic activity of these BAIs may offer potential therapeutic benefits.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: BAI3 polyclonal Antibody detects endogenous levels of BAI3 protein.

Molecular Weight: ~ 172 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Brain-specific angiogenesis inhibitor 3; BAI3; KIAA0550

Immunogen: A synthetic peptide corresponding to residues in Human BAI3

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: