Balicatib | 2596

Cell-permeable. Balicatib is a potent human cathepsin K inhibitor in vitro (IC₅₀ = 1.4 nM) with a high selectivity against human cathepsins B, L, and S (> 4,800-fold, > 500-fold and > 65,000-fold, respectively).

Balicatib is a potent human cathepsin K inhibitor in vitro (IC₅₀ = 1.4 nM) with a high selectivity against human cathepsins B, L, and S (> 4,800-fold, > 500-fold and > 65,000-fold, respectively).

2596 | Balicatib DataSheet

Alternate Name/Synonyms: N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(4-propylpiperazin-1-yl)benzamide; AAE581

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 354813-19-7

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₃₃N₅O₂

Molecular Weight: 411.54

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (~ 4 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent cathepsin K inhibitor

MDL Number: N/A

PubChem CID: 10201696

SMILES: CCCN1CCN(C2=CC=C(C(NC3(C(NCC#N)=O)CCCCC3)=O)C=C2)CC1

InChi: InChI=1S/C23H33N5O2/c1-2-14-27-15-17-28(18-16-27)20-8-6-19(7-9-20)21(29)26-23(10-4-3-5-11-23)22(30)25-13-12-24/h6-9H,2-5,10-11,13-18H2,1H3,(H,25,30)(H,26,29)

InChi Key: LLCRBOWRJOUJAE-UHFFFAOYSA-N