Baricitinib | 2842

Baricitinib is a selective JAK1 and JAK2 inhibitor with IC₅₀ values of 5.9 nM and 5.7 nM, respectively. Baricitinib is ~70 and ~10-fold selective versus JAK3 and Tyk2, with no inhibition to c-Met and Chk2.

Baricitinib is a selective JAK1 and JAK2 inhibitor with IC₅₀ values of 5.9 nM and 5.7 nM, respectively. Baricitinib is ~70 and ~10-fold selective versus JAK3 and Tyk2, with no inhibition to c-Met and Chk2.

2842 | Baricitinib DataSheet

Alternate Name/Synonyms: 2-[1-Ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetonitrile; INCB 028050;LY 3009104;INCB028050;LY3009104;LY-3009104;INCB-028050

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1187594-09-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₇N₇O₂S

Molecular Weight: 371.42

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective JAK1 and JAK2 inhibitor

MDL Number: N/A

PubChem CID: 44205240

SMILES: CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

InChi: InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)

InChi Key: XUZMWHLSFXCVMG-UHFFFAOYSA-N