BAY 11-7082 | 1867

Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. Inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC₅₀ values of 5-10 µM.

BAY 11-7082 is an anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation.

1867 | BAY 11-7082 DataSheet

Alternate Name/Synonyms: (E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 19542-67-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₉NO₂S

Molecular Weight: 207.25

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO or EtOH

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A NF-κB activation inhibitor

MDL Number: MFCD00712162

PubChem CID: 5353431

SMILES: CC1=CC=C(C=C1)S(=O)(=O)C=CC#N

InChi: InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

InChi Key: DOEWDSDBFRHVAP-KRXBUXKQSA-N